Year: 2015 | Month: June | Volume 5 | Issue 2
Effect of Epidural Administration of Promethazine With and Without Bupivacaine on Biochemical Attiributes of Canines
Abstract:
Six apparently healthy nondescript adult dogs weighing 15 to 20 kg were used for investigation on effects of Bupivacaine Hydrochloride and Promethazine as epidural anesthetic on Biochemical attributes. Nine serum samples from each dog were collected at 0, 3, 6, 12, 24, 48, 72, and at 96 h post treatment for the estimation of Blood Glucose, Serum Glutamic Pyruvic Transaminase (SGPT), Serum Alkaline Phosphatase (SAP), Total Bilirubin and serum creatinine. It was observed that the Blood Glucose levels rise after administration of Promethazine alone and with Bupivacaine and achieved peak on 72 h post administration and then declined. Serum Total Protein levels remain unaffected after administration of Promethazine alone while along with Bupivacaine increase in total serum protein during different time interval with peak value recorded at 24 h post administration. SGPT levels increased and reached peak at 12 h post administration after administration of Promethazine alone and with combination with Bupivacaine. SAP values followed trends of SGPT and reached peak at 12 h post administration and then declining gradually in both treatments. The Blood creatinine values increased gradually post administration in both treatments and achieved peak at 48 h post administration and then declining gradually.
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